It is not trivial to determine the fraction of fibroblasts in tissue. Such analysis may be of interest e.g. for research on fibrosis or cell free DNA. We have determined DNA methylation patterns that correlate with the fraction of fibroblasts in tissue. Cygenia offers service for a Fibro-Score based on two CpGs that can be used to estimate the fraction of fibroblasts.
Schmidt et al. Deconvolution of cellular subsets in human tissue based on targeted DNA methylation analysis at individual CpG sites. BMC Biology, 2020.